Original Research Article
Year: 2023 | Month: January-March | Volume: 8 | Issue: 1 | Pages: 234-239
DOI: https://doi.org/10.52403/ijshr.20230133
Thyroid Abnormalities in Children with Sepsis
Dr. Sushila Kumari1, Dr. Kailash Kumar Meena2, Dr. Umesh K. Gurjar3, Dr. Subhash Dhayal4, Dr. Janak Raj Soni5
1Resident Doctor, Dept. Of Paediatrics, SMS MC Jaipur
2Senior Professor and Unit Head, Dept. Of Paediatrics, SMS MC Jaipur
3Assistant Professor, Dept of Pediatrics, SMS MC Jaipur
4Resident Doctor, Dept. Of Ophthalmology, PMCH Udaipur
5Resident Doctor, Dept. Of OBEST. & GYNEC. SMS Medical College, Jaipur
Corresponding Author: Dr. Janak Raj Soni
ABSTRACT
Introduction: Sepsis is the most common cause of mortality in infants and children. A hormonal disorder that often affected in sepsis is thyroid hormones which occur in the form of euthyroid sick syndrome (ESS) or nonthyroidal illness syndrome (NTIS). The aim of study was to evaluate thyroid hormones changes and the outcome in children with sepsis.
Materials and Methods: Present study is hospital based observational cohort study.70 children with diagnosed sepsis were required in sample size. Serum free T3, free T4 and TSH was measured on day one and also on follow up (7th day).
Result: on day one Serum FT3 level was low in 40 (57.2%) subjects and Serum FT4 level was low in 12 (17.2%) subjects. TSH was normal in most 66 (94.2%) of subjects. Mortality was more in children with low serum FT3 (22.5%) as compared to those with normal FT3 (3.4%). Mortality was also more in children with low serum FT4 level (41.6%) as compared to those with normal FT4 level (8.7%), (p=0.002). Mortality was more in children with low serum FT3 (29%) on follow up as compared to those with normal FT3 (2.5%) (p=0.001).
Conclusion: Thyroid hormones dysfunctions are common in children with sepsis. Mortality is significantly associated with low levels of serum FT3 & FT4. So Thyroid hormones dysfunctions could be an indicator of disease severity with possible need for hormone supplementation.
Keywords: Thyroid hormones, Serum free T3, free T4, TSH, sepsis, children