Original Research Article
Year: 2022 | Month: April-June | Volume: 7 | Issue: 2 | Pages: 372-378
DOI: https://doi.org/10.52403/ijshr.20220452
A Validated Method for Estimation of Rivastigmine Pure and Its Pharmaceutical Formulations by UV Spectroscopy
Mohamed Zerein Fathima. M1, R. Sundhararajan2, C. Roosewelt3, Azeez Ur Rahman G4, Buhari Ramalan M.H.L4, Mohammed Irbaz. N4, Rayan4, Swarnakumar S4
1,2,3,4Mohamed Sathak Aj College of Pharmacy, Chennai.
Corresponding Author: Mohamed Zerein Fathima. M
ABSTRACT
A Simple, Rapid, Precise and Accurate UV Spectrophotometric method was developed and validated for the estimation of Rivastigmine in capsule dosage form. From the solubility profile 0.1M HCl was chosen as a solvent for the estimation of Rivastigmine. The sample solutions of 10 μg mL-1 of Rivastigmine prepared individually. 216 nm was selected as wavelength. The LOD and LOQ for estimation of Rivastigmine were 0.44 μg/ml, 1.44 μg/ml respectively. This method is simple, rapid and economically competitive with other published methods and also this method is very sensitive and free from interferences and can be used for routine analysis.
Keywords: Rivastigmine, UV, Ruggedness, Robustness.