Original Research Article
Year: 2022 | Month: January-March | Volume: 7 | Issue: 1 | Pages: 41-45
DOI: https://doi.org/10.52403/ijshr.20220108
Comparison of Efficacy of Oral Antidiabetic Drugs versus Combination of Oral Antidiabetic Drugs along with Insulin in Management of Diabetes Mellitus – A Retrospective Study
Kunal Gupta1, Saurav Deka2, Betina Chandolia3, Raman Gupta4
1MBBS, MD, Diabetologist, Kosmos Superspeciality Hospital, Delhi NCR
2MBBS, MD, AVP, RWE, THB Sekhmet Technologies, Gurgaon
3BDS, MDS, Medical Writer, RWE, THB Sekhmet Technologies, Gurgaon
4BSc, MSc, Biostatistician, RWE, THB Sekhmet Technologies, Gurgaon
Corresponding Author: Kunal Gupta
ABSTRACT
Objective: To compare the efficacy of oral antidiabetic drugs (OADs) versus combination of OADs along with insulin in Type 2 Diabetes Mellitus patients.
Methods: A retrospective study was conducted in which data was extracted from the electronic medical records. Two groups were formed, Group I comprised of nineteen patients who were prescribed OADs while in Group II, five patients were prescribed combination of OADs and insulin therapy from January 2020 to June 2021. Blood glucose parameters (HbA1c, FBS, PPBS) were noted at baseline and subsequent next three follow-ups. The statistical analysis was done using SPSS version 26.0.
Results: The diabetic patients on the combination therapy showed better improvement as compared to the diabetic patients who were prescribed only OADs. However, the differences between the blood glucose parameters were found to be non-significant.
Conclusion: In the case of patients where targeted glucose levels are not achieved with OADs alone, combination therapy can be prescribed comprising of OADs and insulin therapy to get better-controlled results.
Keywords: Oral antidiabetic drugs (OADs), combination of OADs & insulin, Type 2 Diabetes Mellitus, T2DM, diabetic patients.