Review Article
Year: 2021 | Month: July-September | Volume: 6 | Issue: 3 | Pages: 366-382
DOI: https://doi.org/10.52403/ijshr.20210762
Pharmacological and Neuroprotective Natural Products in the Treatment of Alzheimer’s Disease
A.Mary Prashanthi1, Vissarapu Naga Lakshmi2
1M.Pharmacy Student, Department of Pharmacology, 2M.Pharmacy Student, Department of Pharmaceutical Chemistry,
Hindu college of pharmacy, Amaravathi Road, Guntur-522002.(A.P), India.
Corresponding Author: A.Mary Prashanthi
ABSTRACT
Alzheimer's illness (AD) is a progressive, neurodegenerative issue and has become an incredible medical condition especially among the old individuals, for the most part happens after the age of 55 years and expansion in frequency with propelling age, however its therapy alternatives are generally not many and inadequate. The reason for AD isn't actually known, yet is thought to incorporate both hereditary and natural elements (multifactorial). There is no known remedy for Alzheimer's sickness, since it is beyond the realm of imagination to expect to invert the demise of synapses however the indications can be overseen by some pharmacological specialists and Neuroprotective Natural Products. In spite of the improvement of various pharmacological methodologies throughout the years pointed toward treating Alzheimer's Disease (AD) without a doubt, not many have been supported for clinical use in patients. To date there still exists no illness adjusting treatment that could forestall or protect the intellectual debilitation, especially of memory aquisition, that is normal for AD. One of the opportunities for this situation may be that most of medication disclosure endeavors centers around result proportions of diminished neuropathological biomarkers normal for AD, without taking into acount neuronal cycles fundamental for the age and support of memory measures. In endeavors to find new methodologies for AD treatment, regular items have stirred interest in the examination local area and in the drug business for their neuroprotective movement, focusing on various obsessive instruments related with AD. A wide assortment of normal items from various beginnings have been assessed preclinically and clinically for their neuroprotective instruments in forestalling and lessening the multifactorial pathologies of AD. It is accepted that normal item blends or concentrates containing different bioactive mixtures that can work additively or synergistically to display various neuroprotective systems may be a compelling methodology in AD drug discovery.
Keywords: Alzheimer’s disease (AD); neurodegenerative disease, natural products, pharmacological agents.