Original Research Article
Year: 2020 | Month: October-December | Volume: 5 | Issue: 4 | Pages: 105-111
A Retrospective Study on Usage of Surgical Antimicrobial Prophylaxis in a Tertiary Care Hospital
Swathi P S1, Geethu Mariya Paul1, Nataraj G N2, Bharathi DR3, Fibin Johnson4
1Pharm D Intern, SJM College of Pharmacy, Chitradurga-577502
2Pharm D Intern, SJM College of Pharmacy, Chitradurga-577502
3Professor, Department of Pharmacology, SJM College of Pharmacy, Chitradurga.577502
4Clinical Pharmacist, Artemis Hospital, Gurgaon, 122001
Corresponding Author: Swathi P S
ABSTRACT
Background: Randomized controlled trails have shown that prophylactic antibiotics are effective in preventing surgical site infections howbeit; it is precarious how the timing of prophylactic antibiotic administration and intra operative re-dosing affects the risk of surgical site infection.
Objectives: To assess the selection of antibiotics for surgical prophylaxis, To evaluate the timing of administration of prophylactic antibiotics, To analyze the duration of prophylactic antibiotics, To assess the re-dosing of antibiotics.
Materials and Methods: A retrospective study was carried out by collecting data of 156 patients who undergo surgery in Basaveshwara medical college hospital and research Centre, Chitradurga. P-value less than 0.05 was taken to indicate significant difference.
Results: Of the 156 patient’s undergone surgery, the absolute risk of getting surgical site infections 0.07 i.e.12 (7.7%) subsequently had surgical site infections. The Relative Risk compared with SSI and Compliance, 0.48; 95 percent Confidence interval, 0.11 to 2.10. The Statistical significance status is Non-significant as P-value is 0.310.
Conclusion: In surgical practice there is considerable variation in the timing of the prophylactic administration of antibiotic and prolonged use of prophylactic antibiotic more than 24 hours is noted. The timing of antibiotic and intra-operative re-dosing is not significantly associated with SSI occurrence. While adherence to the timely prophylactic antibiotic measure is not bad care, there is little evidence to suggest that it is better care. Future effort for reducing SSI should strongly co-relate with improved outcomes and include studies to refine recommended antibiotic choice and re-dosing.
Keywords: SAP, SSI, Antimicrobials, Antibiotics, Re-dosing, Timing, Duration.