Review Article
Year: 2020 | Month: July-September | Volume: 5 | Issue: 3 | Pages: 202-213
Polycystic Ovary Syndrome (PCOS): Current and Future Therapy
Maged MN1, Mohamed MN2, Lamia H.Shehata3
1Mazahmiya Hospital, Ministry of Health, Kingdom of Saudi Arabia,
2Department of Ob/Gyn, King Fahd Hospital, Ministry of Health, Kingdom of Saudi Arabia,
3Department of Surgery, Care National Hospital, Kingdom of Saudi Arabia.
Corresponding Author: Maged MN
ABSTRACT
Polycystic ovary syndrome (PCOS) is a multifaceted condition portrayed by constant anovulation and excess ovarian activity, as opposed to different reasons for anovulation that include ovarian lethargy or essential inadequacy. Ongoing examinations showed that PCOS is related with second rate ceaseless aggravation and that women with PCOS are at expanded danger of non-alcoholic fatty liver disease. The inflammatory and metabolic disturbances related with PCOS are clarified to some extent by the conjunction of insulin resistance and obesity however are additionally filled by the androgen abundance. New bits of knowledge into the guideline of hormones and cytokines in muscle and fat tissue bolster the idea that PCOS is a foundational condition. The therapeutic arrangement ought to be customized to the patient phenotype, complaints, and reproductive desire. Of note, the aromatase inhibitor letrozole is by all accounts more powerful than the reference medicate clomiphene citrate to treat barrenness due to PCOS. Fundamental administration by a multidisciplinary team may help the patients to adhere to lifestyle interventions and in this way lessen body adiposity and recuperate their metabolic and reproductive health.
Keywords: Polycystic ovary syndrome, PCOS, insulin resistance, infertility, menstrual irregularity