Review Article
Year: 2020 | Month: January-March | Volume: 5 | Issue: 1 | Pages: 55-60
IL-8 as a Potential Diagnostic Salivary Biomarker in Periodontal Diseases- A Systematic Review
Jyoti Chand1, Sachit Anand Arora2, Shivjot Chhina3
1MDS (3rd year), Post graduate student in the Department of Periodontics,
I.T.S. Dental College, Hospital & Research Centre, Greater Noida
2MDS (Prof. & Principal), Department of Periodontics, I.T.S. Dental College, Hospital & Research Centre, Greater Noida
3MDS (Prof. & Head), Department of Periodontics, I.T.S. Dental College, Hospital & Research Centre, Greater Noida
Corresponding Author: Jyoti Chand
ABSTRACT
IL-8(Chemokine) stimulate the recruitment of inflammatory cells and thus known to play a major role in the initiation and progression of any inflammation, Current systematic review aimed in finding role of salivary IL-8 as a biomarker in Periodontal Diseases, despite of having an important role in the pathogenesis of Periodontal diseases only few studies were done till date to find its co-relation with Periodontitis, Electronic searches of the PubMed, and Scopus databases were conducted from 2000 to 2016 for literature detecting IL-8 levels in individuals with CP compared with healthy individuals in the saliva of the patients. Only 5 Publications till date reported with levels of salivary Il-8 in CP, overall systematic review reported contradictory findings regarding IL-8 levels in patients with Chronic Periodontitis when compared with healthy controls, thus more number of longitudinal studies are required to conform the exact co-relation.
Keywords: Gingivitis, Periodontitis, ELISA, IL-8, Saliva, Oral health, Biochemical analysis, Inflammation