Original Research Article
Year: 2019 | Month: October-December | Volume: 4 | Issue: 4 | Pages: 185-190
Prevalence of Diabetic Peripheral Neuropathy (DPN) In Diabetic Foot Infection (DFI) and Clinical Response of Clindamycin in DPN Positive DFI
Shafia Siddiqui1, Sadiya Mustafavi1, Tanveer Yousra1, Syed Mohammed Sajjad Husayni2
1Department of pharmacy, OHRC, Hyderabad, Telangana, India
2Assistant Professor, Department of General Surgery, Owaisi Hospital & Research Centre, DCMS, Hyderabad, India.
Corresponding Author: Shafia Siddiqui
ABSTRACT
Background: Diabetic foot infection is one of the major complications of diabetes and that it is largely preventable.
Materials and Method: This was an observational study in which we recruited patients >18 years of age, with Diabetic foot infection. Detailed history and clinical examination of all patients were taken at admission. Patients were classified as per IDSA classification of Diabetic Foot Infection. The patient data including the diabetic status, antibiotic therapy, neuropathy, along with glycemic control were recorded. All the data were subjected to statistical analysis and p-value was calculated.
Results and Conclusion: The mean age of male patients was found to be 57.8±9.3 years and that of female patients was found to be 54.5±15.9 years. Higher numbers of patients were found in 50-70 years age group which comprised of 16 (59%) patients. The prevalence of diabetic peripheral neuropathy in Diabetic foot infection patients was found to be 63%. The mean± SD for duration of total antibiotic therapy among the DPN positive and negative patients was 7.41±3.10 and 5.10±2.13 respectively. In our study, according to IDSA classification majority of patients were found having moderate DFI (44.4%).We conclude that DPN positive patients require higher duration of antibiotic therapy and individualized regimen to improve wound healing and reduce the risk of amputation.
Keywords: IDSA, Diabetic Peripheral Neuropathy, Diabetic foot infection, Diabetic foot ulcer, clindamycin, antibiotics