Original Research Article
Year: 2019 | Month: July-September | Volume: 4 | Issue: 3 | Pages: 194-198
Increased Prevalence of Auto Immunity among Pregnant Women in Kolkata, West Bengal - Is Hypovitaminosis D to Be Blamed For It?
Dr. Rinini Dastidar1, Mrs. Tirna Halder2
1Associate Professor & Consultant Biochemist, Department of Biochemistry, Ramakrishna Mission Seva Pratishthan Vivekananda Institute of Medical Sciences
2Director, CEO of OrciVita Sciences & Research Pvt. Ltd
Corresponding Author: Dr. Rinini Dastidar
ABSTRACT
Aim: A cross-sectional study was conducted at Ramakrishna Mission Seva Pratishthan (RKM), Kolkata to evaluate the correlation between the vitamin D level and thyroid function among Bengalee women in the first trimester of their pregnancy.
Methods: The cross sectional study was conducted at the Dept. of Biochemistry, RKM among women who registered in the Obstetrics over a period of three months. Patients were screened based on the inclusion exclusion criteria. 506 patients were included in the study and their TSH, FT4, Vitamin D, Anti TPO levels were measured based on which they were classified as Gestational Hypothyroid and Euthyroid patients.
Results: A shocking 72% was found to be Gestational Hypothyroid (based on Indian Thyroid Association guidelines) and 141 were Euthyroids. Very high Vitamin D deficiency was observed in the entire study population but it was more prevalent among GHT mothers in comparison to euthyroids. Vitamin D and Anti TPO levels were found to be significantly negatively correlated (r= - 0.4498, p <0.0001) among the Gestational Hypothyroid patients. Significant differences of serum TSH, Vitamin D and Anti TPO levels (put the results a vs b) were observed in gestationally hypothyroid mothers as compared to euthyroid women.
Conclusion: The study highlights the significant contribution of vitamin D in causing thyroid auto immunity among gestational mothers thus emphasizing the need of antenatal thyroid screening and vitamin D supplementation.
Keywords: Vitamin D deficiency, gestational hypothyroid, euthyroid, TSH