Original Research Article
Year: 2019 | Month: January-March | Volume: 4 | Issue: 1 | Pages: 54-59
Role of Antithrombin III, Plasminogen, Protein C and Protein S in Deep Vein Thrombosis in Indian Population
Shipra Singhal1, Sunil Ranga2, A S Chawla3, Rajat Kamra4
1MD Pathology, Senior Resident, Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi-110029
2MD Pathology, Professor and Consultant, Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi-110029
3MS Surgery, Professor and consultant, Department of Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi-110029
4MS Surgery, Senior Resident, Department of Oncosurgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi-110029
Corresponding Author: Shipra Singhal
ABSTRACT
Deep vein thrombosis is a common condition which is often underdiagnosed. A deficiency of antithrombin III, plasminogen, protein C or protein S, may be associated with a prothrombotic state and can predispose patients to an increased risk of developing deep vein thrombosis. Deficiencies of these anticoagulant proteins may be acquired or congenital. Congenital anticoagulant protein deficiency should be suspected in patients with recurrent deep vein thrombosis without identifiable risk factors. The recognition of this entity is important to prevent development of complications like pulmonary thromboembolism which may prove to be fatal. Role of anticoagulant protein deficiencies as a cause of deep vein thrombosis is scantly studied in the Indian population. The aim of this study is to determine the role of these anticoagulant protein deficiencies as a cause of deep vein thrombosis.
Keywords: Deep vein thrombosis, DVT, Venous thromboembolism (VTE), antithrombin III, plasminogen, protein C, protein S.