Original Research Article
Year: 2018 | Month: October-December | Volume: 3 | Issue: 4 | Pages: 283-285
The Effect of Pepino (Solanum Muricatum Aiton) Extract on Blood Glucose Level in Type 2 Diabetic Rats
Novia Nurul Chaerunnisa1, Iffah Suarsi1, Djunaidi M Dachlan2, Devintha Virani2, Andi Imam Arundhana2
1Undergraduate Student, Nutrition Department, Hasanuddin University, Indonesia
2Nutrition Department, Hasanuddin University, Indonesia
Corresponding Author: Andi Imam Arundhana
ABSTRACT
Pepino contains of flavonoid and phenol as antioxidant which can reduce blood glucose level. This research was aimed to study the effect of pepino extract on blood glucose level in type 2 diabetic rats. The study was used randomized pre-posttest control group design. The subjects of this study were 20 male wistar rats divided into 4 groups, they are control group, the group of pepino extract dosage 250 mg/kg, Pepino extract dosage 500 mg/kg body weight (BW), and preventive group. Rats were induced diabetes with alloxan. Pepino extract was supplied for 2 weeks. Blood glucose level was evaluated every week. Results showed that pepino extract affect blood glucose level in diabetic rats (p<0.05). Results of analysis showed the significant difference between control group with the groups of pepino extract dosage 250 mg/kg BW and dosage 500 mg/kg BW (p<0.05). Meanwhile, there was no significant difference between pepino extract dosage 250 mg/kg BW at a dose of 500 mg/kg BW (p>0.05). Pepino extract dosage 250 mg/kg BW was found to have the same effectiveness as 500 mg/kg BW dose to decrease blood glucose level.
Keywords: Diabetes mellitus, blood glucose level, pepino extract