Year: 2025 | Month: January-March | Volume: 10 | Issue: 1 | Pages: 40-53
DOI: https://doi.org/10.52403/ijshr.20250105
Understanding Lipid Abnormalities in Schizophrenia: A Review of Cholesterol and Triglyceride Levels Pre- and Post-Treatment
Pinku Mazumdar
Department of Biochemistry, Lokopriya Gopinath Bordoloi Regional Institute of Mental Health, Tezpur, Assam. Pin-784001, India
ABSTRACT
Schizophrenia is a complicated mental condition that profoundly impairs cognitive and behavioral abilities, frequently disrupting everyday living and leading to poor health outcomes. Among the many health concerns connected with schizophrenia, lipid metabolic abnormalities, particularly in total cholesterol and serum triglyceride levels, have received attention due to their impact on cardiovascular health. This literature review examines the link between schizophrenia and lipid profiles, with an emphasis on drug-naive patients, those receiving antipsychotic medication, and first-degree relatives. This review, which synthesizes findings from several studies, highlights the impact of antipsychotic medicines on lipid levels, identifies potential biomarkers for schizophrenia, and emphasizes the importance of monitoring lipid metabolism in patients. It also looks at the historical context of lipid abnormalities in schizophrenia, including early observations and current research relating metabolic changes to the disorder's etiology. The review continues by exploring the therapeutic significance of these findings, emphasizing the need for integrated care approaches that address both mental and metabolic health in schizophrenia patients.
Keywords: Schizophrenia, Lipid Metabolism, Total Cholesterol, Serum Triglycerides, Antipsychotic Treatment